Scientific Notes Archive - Page 2 of 16

Flowchart showing the steps used to create patient-derived tumor organoids (PDTOs): starting at left with a human silhouette and icons for “biological fluids” and “tumor”, followed by enzymatic/mechanical dissociation equipment; a tube containing isolated cells; embedding of cells in an extracellular-matrix dome inside a culture well; addition of enriched medium; formation of PDTOs; parallel branches for characterization (histology slide, sequencing machine), research assays (multi-well plate, radiation symbol, pill), and cryopreservation (vial rack); arrows trace feedback from PDTO characterization back to the original tumor to correlate findings.

Breast cancer organoid: A short history of innovation in breast cancer treatment

Breast cancer has long been one of the most prevalent and challenging cancers worldwide, demanding constant

Cherry Biotech_breast-cancer-animal-models-pros-and-cons-table

Breast cancer organoids as alternative to animal models

Breast cancer remains the most frequently diagnosed malignancy in women worldwide and a leading cause of

$Schematic representation of an adipose-tissue-on-chip module illustrating the principal engineering elements that enhance physiological relevance: (i) perfusable lumen with circulating immune cells permitting real-time trafficking; (ii) endothelial monolayer aligned by shear stress to maintain a selective barrier; (iii) continuous perfusion for nutrient delivery and waste removal; (iv) controlled gas exchange enabling oxygen tuning and hypoxia modelling; (v) intrinsic, perfused microvasculature embedded within the stromal-vascular fraction; and (vi) fluidic coupling to a downstream liver compartment to study multi-organ crosstalk. A legend identifies the main cell types and extracellular matrix components.$