Nano4Stroke
Anti-inflammatory miRNA nanoshuttles as therapeutic strategy for stroke
Objectives
- Develop and select liposomes encapsulated miRNA with an activity on post stroke inflammation
- Develop a neuro vascular Unit (NVU) on chip to test the anti-inflammatory potential of the developed encapsulated miRNA
- Compare in vitro and in vivo data of the efficacy of anti-inflammatory miRNA
Our role - Nano4Stroke
To generate an ischemic NVU-on-chip model, WP2 will rely on the CubiX microenvironment controller developed by P2 and will entail the development of a new tailored culture unit based on the expertise of P4 on ischemic NVU.
Four steps will be needed:
- Development of ischemic NVU-on-chip prototype (specification sheet writing, designing, prototyping, quality control);
- Establishment of first protocol of use and hardware iterations;
- Refinement of the protocol;
- Biological validation of the culture unit.
Expected Results
- Obtained an in vitro model for a functional healthy or ischemic Blood Brain Barrier.
2. Functionalize liposomes to be recruited by an inflamed (stroke mimicking condition) for a target delivery
3. Selecting for the best anti-inflammatory miRNA, focusing on clinical results and applications
Managing team
Pierre Gaudriault
Cherry Biotech
Scientific Project Manager
Antoni Homs Corbera
Cherry Biotech
MPS Developement Responsible
Dario Fassini
Cherry Biotech
Biological Model Validation Responsible
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Our expertise combines Microfluidic, 3DCell culture, Microscopy, Omics and artificial intelligence.
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